Assay Detail
Binding
CHEMBL5548729
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate incubated for 60 mins in presence of ATP by ADP-glo reagent based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (CHEMBL2292) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Psychoplastogenic DYRK1A Inhibitors with Therapeutic Effects Relevant to Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.97 | 7.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269538 | HARMINE | 1.0 | 1 | 7.69 |
| CHEMBL408982 | — | — | 1 | 7.24 |
| CHEMBL5594692 | — | — | 1 | 6.68 |
| CHEMBL5567330 | — | — | 1 | 6.25 |
| CHEMBL5575454 | — | — | 1 | - |
| CHEMBL5569583 | — | — | 1 | - |
| CHEMBL5574812 | — | — | 1 | - |
| CHEMBL5573704 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269538 | HARMINE | IC50 | = | 20.5 | nM | 7.69 |
| CHEMBL408982 | — | IC50 | = | 57.3 | nM | 7.24 |
| CHEMBL5594692 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL5567330 | — | IC50 | = | 561.0 | nM | 6.25 |
| CHEMBL5575454 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5569583 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5574812 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5573704 | — | IC50 | > | 10000.0 | nM | - |