Assay Detail
Binding
CHEMBL5549064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to TTR in human plasma assessed as target occupancy incubated for 6 hrs in presence of E)-S-phenyl 3-(4-hydroxy-3,5-dimethyistyryl)benzothioate by fluorescence based competitive binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.35 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5566935 | — | — | 1 | 5.60 |
| CHEMBL5570538 | — | — | 1 | 5.57 |
| CHEMBL5575152 | — | — | 1 | 5.52 |
| CHEMBL5570396 | — | — | 1 | 5.46 |
| CHEMBL5573622 | — | — | 1 | 5.41 |
| CHEMBL232201 | BENZIODARONE | 4.0 | 1 | 5.05 |
| CHEMBL2103837 | TAFAMIDIS | 4.0 | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5566935 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5570538 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5575152 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5570396 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5573622 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL232201 | BENZIODARONE | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL2103837 | TAFAMIDIS | EC50 | = | 15600.0 | nM | 4.81 |