Assay Detail
Binding
CHEMBL5549065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of acid-induced TTR V30M mutant (unknown origin) aggregation preincubated for 30 mins followed by acetate buffer at pH 4.7 addition and measured after 7 days by thioflavin T based fluorescence analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.25 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5566935 | — | — | 1 | 5.30 |
| CHEMBL5570538 | — | — | 1 | 5.28 |
| CHEMBL5573622 | — | — | 1 | 5.27 |
| CHEMBL5575152 | — | — | 1 | 5.21 |
| CHEMBL5570396 | — | — | 1 | 5.19 |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5566935 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5570538 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5573622 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5575152 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5570396 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL388590 | BENZBROMARONE | IC50 | ~ | 5000.0 | nM | - |