Assay Detail
Binding
CHEMBL5549067
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Binding affinity to TTR V30M mutant (unknown origin) assessed as dissociation constant by ITC analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 7.16 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5575152 | — | — | 1 | 7.40 |
| CHEMBL5570538 | — | — | 1 | 7.38 |
| CHEMBL5573622 | — | — | 1 | 7.28 |
| CHEMBL5566935 | — | — | 1 | 7.18 |
| CHEMBL232201 | BENZIODARONE | 4.0 | 1 | 7.11 |
| CHEMBL5570396 | — | — | 1 | 6.92 |
| CHEMBL2103837 | TAFAMIDIS | 4.0 | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5575152 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL5570538 | — | Kd | = | 42.0 | nM | 7.38 |
| CHEMBL5573622 | — | Kd | = | 53.0 | nM | 7.28 |
| CHEMBL5566935 | — | Kd | = | 66.0 | nM | 7.18 |
| CHEMBL232201 | BENZIODARONE | Kd | = | 78.0 | nM | 7.11 |
| CHEMBL5570396 | — | Kd | = | 120.0 | nM | 6.92 |
| CHEMBL2103837 | TAFAMIDIS | Kd | = | 138.0 | nM | 6.86 |