Assay Detail
Binding
CHEMBL5550325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NAMPT (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL1744525) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Drug discovery targeting nicotinamide phosphoribosyltransferase (NAMPT): Updated progress and perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.79 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3586462 | — | — | 1 | 8.51 |
| CHEMBL5575726 | — | — | 1 | 8.00 |
| CHEMBL3105156 | — | — | 1 | 7.72 |
| CHEMBL4297467 | PADNARSERTIB | 2.0 | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3586462 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL5575726 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3105156 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4297467 | PADNARSERTIB | IC50 | = | 120.0 | nM | 6.92 |