Assay Detail
Functional
CHEMBL5550335
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Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as inhibition of viral DNA replication treated from day 2 to day 8 by real time fluorescence qPCR analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2.2.15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of tenofovir monobenzyl ester phosphonoamidate prodrugs with improved anti-hepatitis B virus activity and intrahepatic tenofovir enrichment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.08 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5574841 | — | — | 1 | 8.47 |
| CHEMBL5570736 | — | — | 1 | 8.22 |
| CHEMBL2107825 | TENOFOVIR ALAFENAMIDE | 4.0 | 1 | 7.75 |
| CHEMBL5592743 | — | — | 1 | 6.67 |
| CHEMBL5591892 | — | — | 1 | 6.56 |
| CHEMBL5575588 | — | — | 1 | 6.54 |
| CHEMBL5594965 | — | — | 1 | 6.38 |
| CHEMBL5574409 | — | — | 1 | 6.07 |
| CHEMBL5570829 | — | — | 1 | - |
| CHEMBL5572044 | — | — | 1 | - |
| CHEMBL5571211 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5574841 | — | EC50 | = | 3.39 | nM | 8.47 |
| CHEMBL5570736 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2107825 | TENOFOVIR ALAFENAMIDE | EC50 | = | 17.75 | nM | 7.75 |
| CHEMBL5592743 | — | EC50 | = | 214.0 | nM | 6.67 |
| CHEMBL5591892 | — | EC50 | = | 274.7 | nM | 6.56 |
| CHEMBL5575588 | — | EC50 | = | 290.1 | nM | 6.54 |
| CHEMBL5594965 | — | EC50 | = | 418.4 | nM | 6.38 |
| CHEMBL5574409 | — | EC50 | = | 847.6 | nM | 6.07 |
| CHEMBL5570829 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5572044 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5571211 | — | EC50 | > | 1000.0 | nM | - |