Assay Detail
Toxicity
CHEMBL5550387
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Cytotoxicity against human SW620 cells incubated for 3 days by CellTiter 96 Aqueous One Solution Proliferation Assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.65 | 4.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5564300 | — | — | 1 | 4.78 |
| CHEMBL5569532 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5564300 | — | IC50 | = | 16580.0 | nM | 4.78 |
| CHEMBL5569532 | — | IC50 | = | 30830.0 | nM | 4.51 |