Assay Detail
Binding
CHEMBL5550437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PIM-1 expressed in bacteria using histone H1 as substrate incubated for 30 mins in presence of ATP by ADP-Glo kinase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of 1H-pyrrolo[3,2-g]isoquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.31 | 6.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5574139 | — | — | 1 | 6.65 |
| CHEMBL5570490 | — | — | 1 | 6.32 |
| CHEMBL5563473 | — | — | 1 | 6.17 |
| CHEMBL5592689 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5574139 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL5570490 | — | IC50 | = | 479.0 | nM | 6.32 |
| CHEMBL5563473 | — | IC50 | = | 675.0 | nM | 6.17 |
| CHEMBL5592689 | — | IC50 | = | 804.0 | nM | 6.09 |