Assay Detail
Binding
CHEMBL5550459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of BODIPY TMR-X-labeled P11 peptide from recombinant N-terminal deca-His/SUMO tagged RTA (1 to 267 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant incubated for 30 mins by competition binding based fluorescence polarization assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 4.90 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5570679 | — | — | 1 | 6.00 |
| CHEMBL5564152 | — | — | 1 | 6.00 |
| CHEMBL5569646 | — | — | 1 | 5.40 |
| CHEMBL5081858 | — | — | 1 | 5.10 |
| CHEMBL1421818 | — | — | 1 | 5.10 |
| CHEMBL5583644 | — | — | 1 | 4.82 |
| CHEMBL5583562 | — | — | 1 | 4.75 |
| CHEMBL1499110 | — | — | 1 | 4.70 |
| CHEMBL5573290 | — | — | 1 | 4.64 |
| CHEMBL3758678 | — | — | 1 | 4.55 |
| CHEMBL1567079 | — | — | 1 | 4.37 |
| CHEMBL3951007 | — | — | 1 | 4.24 |
| CHEMBL5573194 | — | — | 1 | 4.03 |
| CHEMBL5573297 | — | — | 1 | - |
| CHEMBL5571688 | — | — | 1 | - |
| CHEMBL1373223 | — | — | 1 | - |
| CHEMBL1366384 | — | — | 1 | - |
| CHEMBL5571408 | — | — | 1 | - |
| CHEMBL5593223 | — | — | 1 | - |
| CHEMBL3758963 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5570679 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL5564152 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL5569646 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL5081858 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL1421818 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL5583644 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL5583562 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL1499110 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL5573290 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL3758678 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL1567079 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL3951007 | — | Ki | = | 58000.0 | nM | 4.24 |
| CHEMBL5573194 | — | Ki | = | 94000.0 | nM | 4.03 |
| CHEMBL5573297 | — | Ki | - | — | - | |
| CHEMBL5571688 | — | Ki | - | — | - | |
| CHEMBL1373223 | — | Ki | - | — | - | |
| CHEMBL1366384 | — | Ki | - | — | - | |
| CHEMBL5571408 | — | Ki | - | — | - | |
| CHEMBL5593223 | — | Ki | - | — | - | |
| CHEMBL3758963 | — | Ki | - | — | - |