Assay Detail
Functional
CHEMBL5550486
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human PC-3 cells incubated for 48 hrs by MTT assay
12
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and antitumor activity of 2-substituted quinazoline-4-amine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.25 | 5.58 |
| IC20 | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.58 |
| CHEMBL5572525 | — | — | 2 | 5.25 |
| CHEMBL5575218 | — | — | 2 | 5.24 |
| CHEMBL5574404 | — | — | 2 | 5.18 |
| CHEMBL1968672 | — | — | 1 | 5.17 |
| CHEMBL5572100 | — | — | 2 | 5.10 |
| CHEMBL5573147 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5572525 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5575218 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL5574404 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1968672 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5572100 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5573147 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5575218 | — | IC20 | = | 7.509 | uM | - |
| CHEMBL5574404 | — | IC20 | = | 0.975 | uM | - |
| CHEMBL5572525 | — | IC20 | = | 0.25 | uM | - |
| CHEMBL5573147 | — | IC20 | = | 0.981 | uM | - |
| CHEMBL5572100 | — | IC20 | = | 7.605 | uM | - |