Assay Detail
Functional
CHEMBL5550487
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562 cells incubated for 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and antitumor activity of 2-substituted quinazoline-4-amine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.78 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5573147 | — | — | 1 | 7.30 |
| CHEMBL5572525 | — | — | 1 | 6.52 |
| CHEMBL1968672 | — | — | 1 | 5.75 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.64 |
| CHEMBL5575218 | — | — | 1 | 5.10 |
| CHEMBL5572100 | — | — | 1 | 5.10 |
| CHEMBL5574404 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5573147 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5572525 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1968672 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5575218 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5572100 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5574404 | — | IC50 | = | 9300.0 | nM | 5.03 |