Assay Detail
Toxicity
CHEMBL5550490
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Antiproliferative activity against HEK293T cells incubated for 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and antitumor activity of 2-substituted quinazoline-4-amine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.47 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5573147 | — | — | 1 | 5.96 |
| CHEMBL5572525 | — | — | 1 | 5.68 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.62 |
| CHEMBL1968672 | — | — | 1 | 5.51 |
| CHEMBL5575218 | — | — | 1 | 5.21 |
| CHEMBL5574404 | — | — | 1 | 5.19 |
| CHEMBL5572100 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5573147 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5572525 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1968672 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5575218 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5574404 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL5572100 | — | IC50 | = | 7900.0 | nM | 5.10 |