Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5550820

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against SARS-CoV-2 USA-WA1/2020 infected in human HeLa cells harbouring ACE2 assessed as reduction in cytopathic effect pretreated with cells followed by viral infection and measured after 24 hrs by fluorescence based analysis
ChEMBL ↗
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Severe acute respiratory syndrome coronavirus 2
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

SARS-CoV-2 (CHEMBL4303835) ↗
Type ORGANISM
Organism Severe acute respiratory syndrome coronavirus 2

Publication

Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity.
Carney DW, Leffler AE, Bell JA, Chandrasinghe AS, Cheng C, Chang E, Dornford A, Dougan DR, Frye LL, Grimes ME, Knehans T, Knight JL, Komandla M, Lane W, Li H, Newman SR, Phimister K, Saikatendu KS, Silverstein H, Vafaei S.
Bioorg Med Chem (2024) 103 : 117577 -117577
PubMed 38518735 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 40 6.16 7.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5565685 — — 1 7.05
CHEMBL5565858 — — 1 6.96
CHEMBL5570210 — — 1 6.92
CHEMBL5574551 — — 1 6.80
CHEMBL5572787 — — 1 6.77
CHEMBL5563513 — — 1 6.71
CHEMBL5591360 — — 1 6.62
CHEMBL5570816 — — 1 6.60
CHEMBL5571280 — — 1 6.57
CHEMBL5590624 — — 1 6.52
CHEMBL5575793 — — 1 6.52
CHEMBL5574569 — — 1 6.52
CHEMBL5567063 — — 1 6.47
CHEMBL5562781 — — 1 6.46
CHEMBL5574928 — — 1 6.43
CHEMBL5571332 — — 1 6.39
CHEMBL5583904 — — 1 6.33
CHEMBL5567237 — — 1 6.28
CHEMBL5572795 — — 1 6.20
CHEMBL5574536 — — 1 6.16
CHEMBL5572085 — — 1 6.14
CHEMBL5571608 — — 1 6.11
CHEMBL5565724 — — 1 5.96
CHEMBL5572886 — — 1 5.89
CHEMBL5562905 — — 1 5.89
CHEMBL5562962 — — 1 5.85
CHEMBL5570525 — — 1 5.75
CHEMBL5570296 — — 1 5.75
CHEMBL5575126 — — 1 5.66
CHEMBL5595277 — — 1 5.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5565685 — EC50 = 90.0 nM 7.05
CHEMBL5565858 — EC50 = 110.0 nM 6.96
CHEMBL5570210 — EC50 = 120.0 nM 6.92
CHEMBL5574551 — EC50 = 160.0 nM 6.80
CHEMBL5572787 — EC50 = 170.0 nM 6.77
CHEMBL5563513 — EC50 = 196.0 nM 6.71
CHEMBL5591360 — EC50 = 240.0 nM 6.62
CHEMBL5570816 — EC50 = 250.0 nM 6.60
CHEMBL5571280 — EC50 = 270.0 nM 6.57
CHEMBL5574569 — EC50 = 300.0 nM 6.52
CHEMBL5575793 — EC50 = 300.0 nM 6.52
CHEMBL5590624 — EC50 = 300.0 nM 6.52
CHEMBL5567063 — EC50 = 340.0 nM 6.47
CHEMBL5562781 — EC50 = 343.0 nM 6.46
CHEMBL5574928 — EC50 = 370.0 nM 6.43
CHEMBL5571332 — EC50 = 410.0 nM 6.39
CHEMBL5583904 — EC50 = 470.0 nM 6.33
CHEMBL5567237 — EC50 = 530.0 nM 6.28
CHEMBL5572795 — EC50 = 630.0 nM 6.20
CHEMBL5574536 — EC50 = 690.0 nM 6.16
CHEMBL5572085 — EC50 = 720.0 nM 6.14
CHEMBL5571608 — EC50 = 770.0 nM 6.11
CHEMBL5565724 — EC50 = 1100.0 nM 5.96
CHEMBL5572886 — EC50 = 1300.0 nM 5.89
CHEMBL5562905 — EC50 = 1300.0 nM 5.89
CHEMBL5562962 — EC50 = 1400.0 nM 5.85
CHEMBL5570525 — EC50 = 1800.0 nM 5.75
CHEMBL5570296 — EC50 = 1800.0 nM 5.75
CHEMBL5575126 — EC50 = 2200.0 nM 5.66
CHEMBL5595277 — EC50 = 2500.0 nM 5.60
CHEMBL5571893 — EC50 = 4000.0 nM 5.40
CHEMBL5573206 — EC50 = 7100.0 nM 5.15
CHEMBL5564296 — EC50 = 8500.0 nM 5.07
CHEMBL5573701 — EC50 = 8800.0 nM 5.06
CHEMBL5573233 — EC50 = 9200.0 nM 5.04
CHEMBL5565166 — EC50 - — -
CHEMBL5573583 — EC50 - — -
CHEMBL5574830 — EC50 - — -
CHEMBL5593300 — EC50 - — -
CHEMBL5593819 — EC50 - — -