Assay Detail
Binding
CHEMBL5550828
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Inhibition of human Cathepsin B
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.96 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5595277 | — | — | 1 | 5.82 |
| CHEMBL5565858 | — | — | 1 | 4.54 |
| CHEMBL5565685 | — | — | 1 | 4.52 |
| CHEMBL5570210 | — | — | 1 | - |
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5595277 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5565858 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL5565685 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL5570210 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4802135 | NIRMATRELVIR | IC50 | > | 50000.0 | nM | - |