Assay Detail
Binding
CHEMBL5550846
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC11 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synergistic therapeutics: Co-targeting histone deacetylases and ribonucleotide reductase for enhanced cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.25 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 9.52 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 8.40 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.57 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 31.0 | nM | 7.51 |