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Assay Detail

CHEMBL5550864

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human PANC-1 cells assessed as inhibition of cell viability incubated for 72 hrs by MTS assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PANC-1
Confidence 1 — Organism
Curated By Autocuration

Target

PANC-1 (CHEMBL614139)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and biological evaluation of aryloxy thiophosphoramidate triesters of anticancer nucleoside analogues.
Serpi M, di Ciano S, Pertusati F.
Bioorg Med Chem (2024) 103 : 117696 -117696
PubMed 38547648 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 6.05 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL428647 PACLITAXEL 4.0 1 8.52
CHEMBL888 GEMCITABINE 4.0 1 6.17
CHEMBL3126004 FOSGEMCITABINE PALABENAMIDE 3.0 1 5.40
CHEMBL5590591 1 4.12
CHEMBL1076257 1 -
CHEMBL2181367 FOSIFLOXURIDINE NAFALBENAMIDE 2.0 1 -
CHEMBL5569356 1 -
CHEMBL305686 CORDYCEPIN 1.0 1 -
CHEMBL5277528 FOSDESDENOSINE SIPALABENAMIDE 2.0 1 -
CHEMBL5579766 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL428647 PACLITAXEL IC50 = 3.0 nM 8.52
CHEMBL888 GEMCITABINE IC50 = 680.0 nM 6.17
CHEMBL3126004 FOSGEMCITABINE PALABENAMIDE IC50 = 3960.0 nM 5.40
CHEMBL5590591 IC50 = 76430.0 nM 4.12
CHEMBL1076257 IC50 - -
CHEMBL2181367 FOSIFLOXURIDINE NAFALBENAMIDE IC50 - -
CHEMBL5569356 IC50 - -
CHEMBL305686 CORDYCEPIN IC50 - -
CHEMBL5277528 FOSDESDENOSINE SIPALABENAMIDE IC50 - -
CHEMBL5579766 IC50 - -