Assay Detail
Functional
CHEMBL5550866
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell viability incubated for 72 hrs by MTS assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of aryloxy thiophosphoramidate triesters of anticancer nucleoside analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.03 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.52 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.40 |
| CHEMBL3126004 | FOSGEMCITABINE PALABENAMIDE | 3.0 | 1 | 6.92 |
| CHEMBL1076257 | — | — | 1 | 6.52 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | 2.0 | 1 | 5.83 |
| CHEMBL5569356 | — | — | 1 | 5.57 |
| CHEMBL5590591 | — | — | 1 | 5.42 |
| CHEMBL5277528 | FOSDESDENOSINE SIPALABENAMIDE | 2.0 | 1 | 5.13 |
| CHEMBL5579766 | — | — | 1 | 4.90 |
| CHEMBL305686 | CORDYCEPIN | 1.0 | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3126004 | FOSGEMCITABINE PALABENAMIDE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1076257 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL5569356 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL5590591 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL5277528 | FOSDESDENOSINE SIPALABENAMIDE | IC50 | = | 7410.0 | nM | 5.13 |
| CHEMBL5579766 | — | IC50 | = | 12560.0 | nM | 4.90 |
| CHEMBL305686 | CORDYCEPIN | IC50 | = | 76780.0 | nM | 4.12 |