Assay Detail
Functional
CHEMBL5550878
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Cytotoxicity against human HT-29 cells assessed as inhibition of cell viability incubated for 72 hrs by MTS assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of aryloxy thiophosphoramidate triesters of anticancer nucleoside analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.85 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.52 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.16 |
| CHEMBL1076257 | — | — | 1 | 6.89 |
| CHEMBL3126004 | FOSGEMCITABINE PALABENAMIDE | 3.0 | 1 | 6.32 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | 2.0 | 1 | 6.28 |
| CHEMBL5569356 | — | — | 1 | 5.55 |
| CHEMBL5277528 | FOSDESDENOSINE SIPALABENAMIDE | 2.0 | 1 | 5.02 |
| CHEMBL5590591 | — | — | 1 | 4.94 |
| CHEMBL305686 | CORDYCEPIN | 1.0 | 1 | 4.58 |
| CHEMBL5579766 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1076257 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3126004 | FOSGEMCITABINE PALABENAMIDE | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL5569356 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL5277528 | FOSDESDENOSINE SIPALABENAMIDE | IC50 | = | 9470.0 | nM | 5.02 |
| CHEMBL5590591 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL305686 | CORDYCEPIN | IC50 | = | 26330.0 | nM | 4.58 |
| CHEMBL5579766 | — | IC50 | = | 57920.0 | nM | 4.24 |