Assay Detail
Functional
CHEMBL5550900
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HepG2 cells assessed as inhibition of cell viability incubated for 72 hrs by MTS assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of aryloxy thiophosphoramidate triesters of anticancer nucleoside analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.93 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.22 |
| CHEMBL3126004 | FOSGEMCITABINE PALABENAMIDE | 3.0 | 1 | 5.94 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 4.78 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | 2.0 | 1 | 4.61 |
| CHEMBL5277528 | FOSDESDENOSINE SIPALABENAMIDE | 2.0 | 1 | 4.60 |
| CHEMBL5579766 | — | — | 1 | 4.60 |
| CHEMBL5569356 | — | — | 1 | 4.59 |
| CHEMBL5590591 | — | — | 1 | 4.57 |
| CHEMBL1076257 | — | — | 1 | 4.27 |
| CHEMBL305686 | CORDYCEPIN | 1.0 | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3126004 | FOSGEMCITABINE PALABENAMIDE | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL5277528 | FOSDESDENOSINE SIPALABENAMIDE | IC50 | = | 25240.0 | nM | 4.60 |
| CHEMBL5579766 | — | IC50 | = | 25270.0 | nM | 4.60 |
| CHEMBL5569356 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL5590591 | — | IC50 | = | 27060.0 | nM | 4.57 |
| CHEMBL1076257 | — | IC50 | = | 53900.0 | nM | 4.27 |
| CHEMBL305686 | CORDYCEPIN | IC50 | = | 77190.0 | nM | 4.11 |