Assay Detail
Binding
CHEMBL5550985
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Inhibition of 6His-tagged wild type CDK12/cyclin K (unknown origin) infected in insect cells incubated for 1 hr by TR-FRET assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Bioisoteres for carboxylic acids: From ionized isosteres to novel unionized replacements.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.29 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5573487 | — | — | 1 | 7.82 |
| CHEMBL518800 | — | — | 1 | 7.80 |
| CHEMBL461557 | — | — | 1 | 7.77 |
| CHEMBL5575551 | — | — | 1 | 7.75 |
| CHEMBL5575056 | — | — | 1 | 7.68 |
| CHEMBL5594035 | — | — | 1 | 7.68 |
| CHEMBL5565816 | — | — | 1 | 7.55 |
| CHEMBL5568619 | — | — | 1 | 7.46 |
| CHEMBL461556 | — | — | 1 | 7.44 |
| CHEMBL5569096 | — | — | 1 | 7.44 |
| CHEMBL5569293 | — | — | 1 | 7.39 |
| CHEMBL5593913 | — | — | 1 | 7.36 |
| CHEMBL5574391 | — | — | 1 | 7.34 |
| CHEMBL5592449 | — | — | 1 | 7.24 |
| CHEMBL5565299 | — | — | 1 | 7.22 |
| CHEMBL5573271 | — | — | 1 | 7.11 |
| CHEMBL5563303 | — | — | 1 | 6.74 |
| CHEMBL5568703 | — | — | 1 | 6.61 |
| CHEMBL5594597 | — | — | 1 | 6.22 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5573487 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL518800 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL461557 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5575551 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5575056 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5594035 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5565816 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5568619 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL461556 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5569096 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5569293 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5593913 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5574391 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5592449 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5565299 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5573271 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5563303 | — | EC50 | = | 182.0 | nM | 6.74 |
| CHEMBL5568703 | — | EC50 | = | 246.0 | nM | 6.61 |
| CHEMBL5594597 | — | EC50 | = | 603.0 | nM | 6.22 |
| CHEMBL14762 | SELICICLIB | EC50 | = | 703.0 | nM | 6.15 |