Assay Detail
Binding
CHEMBL5551298
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Inhibition of CDK6/Cyclin D1 in human MCF7 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and preclinical evaluations of TQB3616, a novel CDK4-biased inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.96 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 8.52 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 8.15 |
| CHEMBL3545110 | RIBOCICLIB | 4.0 | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3545110 | RIBOCICLIB | IC50 | = | 60.0 | nM | 7.22 |