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Assay Detail

CHEMBL5551970

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and structural optimization of oncolytic peptide LTX-315.
Song M, Liu Q, Yao JF, Wang YT, Ma YN, Xu H, Yu QY, Li Z, Du SS, Qi YK.
Bioorg Med Chem (2024) 107 : 117760 -117760
PubMed 38762978 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.62 4.84

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5569031 1 4.84
CHEMBL5555708 1 4.78
CHEMBL5570934 1 4.77
CHEMBL5572304 1 4.74
CHEMBL5569116 1 4.73
CHEMBL5573214 1 4.59
CHEMBL5570540 1 4.57
CHEMBL4297628 RUXOTEMITIDE 2.0 1 4.48
CHEMBL5592571 1 4.09
CHEMBL5575797 1 -
CHEMBL5569179 1 -
CHEMBL5569341 1 -
CHEMBL5281642 1 -
CHEMBL5574625 1 -
CHEMBL5566396 1 -
CHEMBL5575177 1 -
CHEMBL5570596 1 -
CHEMBL5571755 1 -
CHEMBL5574505 1 -
CHEMBL5566343 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5569031 IC50 = 14400.0 nM 4.84
CHEMBL5555708 IC50 = 16800.0 nM 4.78
CHEMBL5570934 IC50 = 17000.0 nM 4.77
CHEMBL5572304 IC50 = 18400.0 nM 4.74
CHEMBL5569116 IC50 = 18600.0 nM 4.73
CHEMBL5573214 IC50 = 25700.0 nM 4.59
CHEMBL5570540 IC50 = 26900.0 nM 4.57
CHEMBL4297628 RUXOTEMITIDE IC50 = 33200.0 nM 4.48
CHEMBL5592571 IC50 = 82000.0 nM 4.09
CHEMBL5575797 IC50 = 246800.0 nM -
CHEMBL5569179 IC50 > 300000.0 nM -
CHEMBL5569341 IC50 > 300000.0 nM -
CHEMBL5281642 IC50 = 267700.0 nM -
CHEMBL5574625 IC50 > 300000.0 nM -
CHEMBL5566396 IC50 = 275800.0 nM -
CHEMBL5575177 IC50 = 286000.0 nM -
CHEMBL5570596 IC50 = 272500.0 nM -
CHEMBL5571755 IC50 = 129600.0 nM -
CHEMBL5574505 IC50 = 154300.0 nM -
CHEMBL5566343 IC50 = 244600.0 nM -