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Assay Detail

CHEMBL5551971

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human U-937 cells incubated for 24 hrs by CCK8 assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-937
Confidence 1 — Organism
Curated By Autocuration

Target

U-937 (CHEMBL612794)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and structural optimization of oncolytic peptide LTX-315.
Song M, Liu Q, Yao JF, Wang YT, Ma YN, Xu H, Yu QY, Li Z, Du SS, Qi YK.
Bioorg Med Chem (2024) 107 : 117760 -117760
PubMed 38762978 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.86 5.13

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5555708 1 5.13
CHEMBL5570934 1 5.10
CHEMBL4297628 RUXOTEMITIDE 2.0 1 4.97
CHEMBL5570540 1 4.96
CHEMBL5569031 1 4.91
CHEMBL5572304 1 4.89
CHEMBL5573214 1 4.87
CHEMBL5569116 1 4.86
CHEMBL5592571 1 4.51
CHEMBL5574505 1 4.39
CHEMBL5566343 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5555708 IC50 = 7400.0 nM 5.13
CHEMBL5570934 IC50 = 8000.0 nM 5.10
CHEMBL4297628 RUXOTEMITIDE IC50 = 10700.0 nM 4.97
CHEMBL5570540 IC50 = 11000.0 nM 4.96
CHEMBL5569031 IC50 = 12300.0 nM 4.91
CHEMBL5572304 IC50 = 12800.0 nM 4.89
CHEMBL5573214 IC50 = 13600.0 nM 4.87
CHEMBL5569116 IC50 = 13800.0 nM 4.86
CHEMBL5592571 IC50 = 31100.0 nM 4.51
CHEMBL5574505 IC50 = 40900.0 nM 4.39
CHEMBL5566343 IC50 = 203800.0 nM -