Assay Detail
Toxicity
CHEMBL5551975
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Cytotoxicity against HUVECs incubated for 24 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structural optimization of oncolytic peptide LTX-315.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.42 | 4.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555708 | — | — | 1 | 4.58 |
| CHEMBL5570934 | — | — | 1 | 4.52 |
| CHEMBL5569116 | — | — | 1 | 4.51 |
| CHEMBL5570540 | — | — | 1 | 4.40 |
| CHEMBL5569031 | — | — | 1 | 4.37 |
| CHEMBL5573214 | — | — | 1 | 4.35 |
| CHEMBL4297628 | RUXOTEMITIDE | 2.0 | 1 | 4.34 |
| CHEMBL5572304 | — | — | 1 | 4.29 |
| CHEMBL5574505 | — | — | 1 | - |
| CHEMBL5566343 | — | — | 1 | - |
| CHEMBL5592571 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555708 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL5570934 | — | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL5569116 | — | IC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL5570540 | — | IC50 | = | 40200.0 | nM | 4.40 |
| CHEMBL5569031 | — | IC50 | = | 42400.0 | nM | 4.37 |
| CHEMBL5573214 | — | IC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL4297628 | RUXOTEMITIDE | IC50 | = | 45400.0 | nM | 4.34 |
| CHEMBL5572304 | — | IC50 | = | 51200.0 | nM | 4.29 |
| CHEMBL5574505 | — | IC50 | = | 104800.0 | nM | - |
| CHEMBL5566343 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5592571 | — | IC50 | = | 106500.0 | nM | - |