Assay Detail
Binding
CHEMBL5552299
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Binding affinity to human N-terminal his tagged Hsp90alpha (1 to 241 residues) expressed in Escherichia coli (DE3) strain assessed as dissociation constant by ITC method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Comprehensive analysis of resorcinyl-imidazole Hsp90 inhibitor design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.51 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5569309 | — | — | 1 | 8.70 |
| CHEMBL5574581 | — | — | 1 | 8.10 |
| CHEMBL5562891 | — | — | 1 | 6.05 |
| CHEMBL5567226 | — | — | 1 | 5.85 |
| CHEMBL5570148 | — | — | 1 | 5.85 |
| CHEMBL5562627 | — | — | 1 | 5.52 |
| CHEMBL5566352 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5569309 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL5574581 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL5562891 | — | Kd | = | 900.0 | nM | 6.05 |
| CHEMBL5567226 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL5570148 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL5562627 | — | Kd | = | 3000.0 | nM | 5.52 |
| CHEMBL5566352 | — | Kd | = | 3300.0 | nM | 5.48 |