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Assay Detail

CHEMBL5552345

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Cytotoxicity against human MCF-10A cells incubated for 24 hrs by CCK-8 reagent based spectrophotometric analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Cell Type MCF-10A
Confidence 1 — Organism
Curated By Autocuration

Target

MCF-10A (CHEMBL614321)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel quinoxaline analogs as telomeric G-quadruplex ligands exert antitumor effects related to enhanced immunomodulation.
Wang JX, Wang XD, Hu MH.
Eur J Med Chem (2024) 274 : 116536 -116536
PubMed 38805936 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.23 5.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5590942 1 5.89
CHEMBL5591675 1 5.82
CHEMBL5574310 1 5.57
CHEMBL5570229 1 5.55
CHEMBL5595910 1 5.47
CHEMBL5571431 1 5.43
CHEMBL5592582 1 5.39
CHEMBL5595301 1 5.24
CHEMBL5569230 1 5.20
CHEMBL5571669 1 5.17
CHEMBL5570356 1 5.06
CHEMBL5569131 1 4.96
CHEMBL5570799 1 4.86
CHEMBL5571174 1 4.75
CHEMBL5563383 1 4.69
CHEMBL5570468 1 4.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5590942 IC50 = 1300.0 nM 5.89
CHEMBL5591675 IC50 = 1500.0 nM 5.82
CHEMBL5574310 IC50 = 2700.0 nM 5.57
CHEMBL5570229 IC50 = 2800.0 nM 5.55
CHEMBL5595910 IC50 = 3400.0 nM 5.47
CHEMBL5571431 IC50 = 3700.0 nM 5.43
CHEMBL5592582 IC50 = 4100.0 nM 5.39
CHEMBL5595301 IC50 = 5800.0 nM 5.24
CHEMBL5569230 IC50 = 6300.0 nM 5.20
CHEMBL5571669 IC50 = 6700.0 nM 5.17
CHEMBL5570356 IC50 = 8800.0 nM 5.06
CHEMBL5569131 IC50 = 11100.0 nM 4.96
CHEMBL5570799 IC50 = 13700.0 nM 4.86
CHEMBL5571174 IC50 = 18000.0 nM 4.75
CHEMBL5563383 IC50 = 20500.0 nM 4.69
CHEMBL5570468 IC50 = 24100.0 nM 4.62