Assay Detail
Binding
CHEMBL5552619
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Inhibition of human PARP1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Poly (ADP-ribose) polymerase (PARP) inhibitors as anticancer agents: An outlook on clinical progress, synthetic strategies, biological activity, and structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.71 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173055 | RUCAPARIB | 4.0 | 1 | 9.10 |
| CHEMBL4112930 | PAMIPARIB | 3.0 | 1 | 8.89 |
| CHEMBL5570455 | — | — | 1 | 8.50 |
| CHEMBL5441085 | — | — | 1 | 8.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4112930 | PAMIPARIB | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5570455 | — | IC50 | = | 3.15 | nM | 8.50 |
| CHEMBL5441085 | — | IC50 | = | 4.4 | nM | 8.36 |