Assay Detail
Functional
CHEMBL5552885
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Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth measured after 8 days by XTT cell viability assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anticancer properties of novel dolastatin 10 analogs featuring five-membered heterocyclic rings with a linkable group at the C-terminus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.13 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5575829 | — | — | 1 | 9.05 |
| CHEMBL5573485 | — | — | 1 | 8.05 |
| CHEMBL6067715 | — | — | 1 | 7.96 |
| CHEMBL5593813 | — | — | 1 | 7.81 |
| CHEMBL5570778 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5575829 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5573485 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL6067715 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL5593813 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL5570778 | — | IC50 | = | 15.7 | nM | 7.80 |