Assay Detail
Binding
CHEMBL5553091
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Binding affinity to biotinylated KRAS G12D mutant (unknown origin) incubated for 120 mins by SPR analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of middle-size cyclic peptides, KRAS inhibitors derived from an mRNA display.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 13 | 9.45 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5573020 | — | — | 1 | 9.85 |
| CHEMBL5562993 | — | — | 1 | 9.80 |
| CHEMBL5572821 | — | — | 1 | 9.77 |
| CHEMBL5570195 | — | — | 1 | 9.74 |
| CHEMBL5569602 | — | — | 1 | 9.72 |
| CHEMBL5575367 | — | — | 1 | 9.64 |
| CHEMBL5576025 | — | — | 1 | 9.59 |
| CHEMBL5570375 | — | — | 1 | 9.49 |
| CHEMBL5565237 | — | — | 1 | 9.33 |
| CHEMBL5572706 | — | — | 1 | 9.19 |
| CHEMBL5591865 | — | — | 1 | 9.12 |
| CHEMBL5569112 | — | — | 1 | 8.96 |
| CHEMBL5566631 | — | — | 1 | 8.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5573020 | — | Kd | = | 0.14 | nM | 9.85 |
| CHEMBL5562993 | — | Kd | = | 0.16 | nM | 9.80 |
| CHEMBL5572821 | — | Kd | = | 0.17 | nM | 9.77 |
| CHEMBL5570195 | — | Kd | = | 0.18 | nM | 9.74 |
| CHEMBL5569602 | — | Kd | = | 0.19 | nM | 9.72 |
| CHEMBL5575367 | — | Kd | = | 0.23 | nM | 9.64 |
| CHEMBL5576025 | — | Kd | = | 0.26 | nM | 9.59 |
| CHEMBL5570375 | — | Kd | = | 0.32 | nM | 9.49 |
| CHEMBL5565237 | — | Kd | = | 0.47 | nM | 9.33 |
| CHEMBL5572706 | — | Kd | = | 0.64 | nM | 9.19 |
| CHEMBL5591865 | — | Kd | = | 0.75 | nM | 9.12 |
| CHEMBL5569112 | — | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL5566631 | — | Kd | = | 2.5 | nM | 8.60 |