Assay Detail
Functional
CHEMBL5553151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against telomerase-positive human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting hTERT Promoter G-Quadruplex DNA Structures with Small-Molecule Ligand to Downregulate hTERT Expression for Triple-Negative Breast Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.56 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5575707 | — | — | 1 | 5.75 |
| CHEMBL5571545 | — | — | 1 | 5.72 |
| CHEMBL5569496 | — | — | 1 | 5.72 |
| CHEMBL5573954 | — | — | 1 | 5.64 |
| CHEMBL5584045 | — | — | 1 | 5.58 |
| CHEMBL5563932 | — | — | 1 | 5.52 |
| CHEMBL5574988 | — | — | 1 | 5.51 |
| CHEMBL5570652 | — | — | 1 | 5.48 |
| CHEMBL5563142 | — | — | 1 | 5.39 |
| CHEMBL5573327 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5575707 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5571545 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5569496 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5573954 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5584045 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5563932 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5574988 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5570652 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5563142 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5573327 | — | IC50 | = | 5500.0 | nM | 5.26 |