Assay Detail
Functional
CHEMBL5553190
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against alternative lengthening of telomere-positive human U2OS cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting hTERT Promoter G-Quadruplex DNA Structures with Small-Molecule Ligand to Downregulate hTERT Expression for Triple-Negative Breast Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.15 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5584045 | — | — | 1 | 5.41 |
| CHEMBL5563932 | — | — | 1 | 5.30 |
| CHEMBL5575707 | — | — | 1 | 5.29 |
| CHEMBL5569496 | — | — | 1 | 5.28 |
| CHEMBL5574988 | — | — | 1 | 5.21 |
| CHEMBL5573954 | — | — | 1 | 5.11 |
| CHEMBL5571545 | — | — | 1 | 5.03 |
| CHEMBL5573327 | — | — | 1 | 5.01 |
| CHEMBL5570652 | — | — | 1 | 4.99 |
| CHEMBL5563142 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5584045 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5563932 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5575707 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5569496 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5574988 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5573954 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5571545 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL5573327 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL5570652 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL5563142 | — | IC50 | = | 14800.0 | nM | 4.83 |