Assay Detail
Toxicity
CHEMBL5553191
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Cytotoxicity against human HK-2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HK-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting hTERT Promoter G-Quadruplex DNA Structures with Small-Molecule Ligand to Downregulate hTERT Expression for Triple-Negative Breast Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.13 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5571545 | — | — | 1 | 5.34 |
| CHEMBL5575707 | — | — | 1 | 5.27 |
| CHEMBL5569496 | — | — | 1 | 5.26 |
| CHEMBL5573954 | — | — | 1 | 5.24 |
| CHEMBL5574988 | — | — | 1 | 5.20 |
| CHEMBL5563932 | — | — | 1 | 5.10 |
| CHEMBL5584045 | — | — | 1 | 5.03 |
| CHEMBL5563142 | — | — | 1 | 5.02 |
| CHEMBL5570652 | — | — | 1 | 5.02 |
| CHEMBL5573327 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5571545 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5575707 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5569496 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL5573954 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5574988 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL5563932 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL5584045 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL5563142 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL5570652 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL5573327 | — | IC50 | = | 14700.0 | nM | 4.83 |