Assay Detail
Toxicity
CHEMBL5553192
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Cytotoxicity against HUVEC cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting hTERT Promoter G-Quadruplex DNA Structures with Small-Molecule Ligand to Downregulate hTERT Expression for Triple-Negative Breast Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.96 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5569496 | — | — | 1 | 5.22 |
| CHEMBL5574988 | — | — | 1 | 5.10 |
| CHEMBL5584045 | — | — | 1 | 5.06 |
| CHEMBL5563932 | — | — | 1 | 5.03 |
| CHEMBL5575707 | — | — | 1 | 4.92 |
| CHEMBL5570652 | — | — | 1 | 4.92 |
| CHEMBL5573327 | — | — | 1 | 4.92 |
| CHEMBL5571545 | — | — | 1 | 4.84 |
| CHEMBL5573954 | — | — | 1 | 4.78 |
| CHEMBL5563142 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5569496 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5574988 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5584045 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL5563932 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL5575707 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL5570652 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL5573327 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5571545 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL5573954 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL5563142 | — | IC50 | = | 16600.0 | nM | 4.78 |