Assay Detail
Functional
CHEMBL5553474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against RSV A2 infected in Normal human bronchial epithelial cells incubated for 3 days by ONE-Glo luciferase assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Respiratory syncytial virus |
| Cell Type | Normal human bronchial epithelial cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Respiratory syncytial virus (CHEMBL612679) ↗| Type | ORGANISM |
| Organism | Respiratory syncytial virus |
Publication
Discovery of GS-7682, a Novel 4'-Cyano-Modified <i>C</i>-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.79 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5562532 | — | — | 1 | 7.82 |
| CHEMBL5567572 | — | — | 1 | 7.77 |
| CHEMBL5570741 | — | — | 1 | 7.72 |
| CHEMBL5571413 | — | — | 1 | 7.64 |
| CHEMBL5591710 | — | — | 1 | 7.39 |
| CHEMBL5570290 | — | — | 1 | 7.34 |
| CHEMBL5575504 | — | — | 1 | 7.29 |
| CHEMBL5573859 | — | — | 1 | 7.27 |
| CHEMBL5568784 | — | — | 1 | 7.25 |
| CHEMBL5571452 | — | — | 1 | 6.85 |
| CHEMBL5567594 | — | — | 1 | 6.78 |
| CHEMBL5571150 | — | — | 1 | 6.53 |
| CHEMBL5579707 | — | — | 1 | 6.20 |
| CHEMBL5571536 | — | — | 1 | 6.03 |
| CHEMBL5569404 | — | — | 1 | 6.03 |
| CHEMBL3425977 | — | — | 1 | 5.64 |
| CHEMBL5570081 | — | — | 1 | 5.45 |
| CHEMBL3608435 | — | — | 1 | 5.21 |
| CHEMBL5568899 | — | — | 1 | - |
| CHEMBL5570710 | — | — | 1 | - |
| CHEMBL5571584 | — | — | 1 | - |
| CHEMBL5573725 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5562532 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5567572 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5570741 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5571413 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5591710 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5570290 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5575504 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5573859 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5568784 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5571452 | — | EC50 | = | 141.0 | nM | 6.85 |
| CHEMBL5567594 | — | EC50 | = | 168.0 | nM | 6.78 |
| CHEMBL5571150 | — | EC50 | = | 295.0 | nM | 6.53 |
| CHEMBL5579707 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5571536 | — | EC50 | = | 933.0 | nM | 6.03 |
| CHEMBL5569404 | — | EC50 | = | 932.0 | nM | 6.03 |
| CHEMBL3425977 | — | EC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL5570081 | — | EC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL3608435 | — | EC50 | = | 6230.0 | nM | 5.21 |
| CHEMBL5568899 | — | EC50 | > | 4300.0 | nM | - |
| CHEMBL5570710 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5571584 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5573725 | — | EC50 | > | 50000.0 | nM | - |