Assay Detail

CHEMBL5553495

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Functional

Anti-viral activity against hMPV CAN99-81 (A1 genotype) infected in rhesus monkey LLC-MK2 cells incubated for 90 mins

ChEMBL ↗

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Target

Human metapneumovirus (CHEMBL615047) ↗

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Human metapneumovirus (CHEMBL615047) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Human metapneumovirus

CHEMBL615047

Anchored from Assay target.

Protein identity Human metapneumovirus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human metapneumovirus
Cell Type	LLC-MK2
Confidence	1 — Organism
Curated By	Autocuration

Target

Human metapneumovirus (CHEMBL615047) ↗

Type	ORGANISM
Organism	Human metapneumovirus

Publication

Discovery of GS-7682, a Novel 4'-Cyano-Modified <i>C</i>-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.

Siegel DS, Hui HC, Pitts J, Vermillion MS, Ishida K, Rautiola D, Keeney M, Irshad H, Zhang L, Chun K, Chin G, Goyal B, Doerffler E, Yang H, Clarke MO, Palmiotti C, Vijjapurapu A, Riola NC, Stray K, Murakami E, Ma B, Wang T, Zhao X, Xu Y, Lee G, Marchand B, Seung M, Nayak A, Tomkinson A, Kadrichu N, Ellis S, Barauskas O, Feng JY, Perry JK, Perron M, Bilello JP, Kuehl PJ, Subramanian R, Cihlar T, Mackman RL.
J Med Chem (2024) 67 : 12945 -12968
PubMed 39018526 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.68	6.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5562532	—	—	1	6.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5562532	—	EC50	=	210.0	nM	6.68