Assay Detail

CHEMBL5553506

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Functional

Anti-viral activity against SARS-CoV-2 infected in human A549 cells expressing hACE2 by firefly reporter assay

ChEMBL ↗

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Target

SARS-CoV-2 (CHEMBL4303835) ↗

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Primary target SARS-CoV-2

CHEMBL4303835

Anchored from Assay target.

Protein identity SARS-CoV-2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Severe acute respiratory syndrome coronavirus 2
Cell Type	A549
Confidence	1 — Organism
Curated By	Autocuration

Target

SARS-CoV-2 (CHEMBL4303835) ↗

Type	ORGANISM
Organism	Severe acute respiratory syndrome coronavirus 2

Publication

Discovery of GS-7682, a Novel 4'-Cyano-Modified <i>C</i>-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.

Siegel DS, Hui HC, Pitts J, Vermillion MS, Ishida K, Rautiola D, Keeney M, Irshad H, Zhang L, Chun K, Chin G, Goyal B, Doerffler E, Yang H, Clarke MO, Palmiotti C, Vijjapurapu A, Riola NC, Stray K, Murakami E, Ma B, Wang T, Zhao X, Xu Y, Lee G, Marchand B, Seung M, Nayak A, Tomkinson A, Kadrichu N, Ellis S, Barauskas O, Feng JY, Perry JK, Perron M, Bilello JP, Kuehl PJ, Subramanian R, Cihlar T, Mackman RL.
J Med Chem (2024) 67 : 12945 -12968
PubMed 39018526 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	6.21	7.10

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4065616	REMDESIVIR	4.0	1	7.10
CHEMBL5562532	—	—	1	5.32

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4065616	REMDESIVIR	EC50	=	80.0	nM	7.10
CHEMBL5562532	—	EC50	=	4750.0	nM	5.32