Assay Detail
Functional
CHEMBL5553576
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Cytotoxicity against human PC-3 cells assessed as reduction in cell viability by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new 1,3-diphenylurea appended aryl pyridine derivatives as apoptosis inducers through c-MET and VEGFR-2 inhibition: design, synthesis, <i>in vivo</i> and <i>in silico</i> studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.62 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5594061 | — | — | 1 | 5.73 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 5.70 |
| CHEMBL5568824 | — | — | 1 | 5.65 |
| CHEMBL5571331 | — | — | 1 | 5.61 |
| CHEMBL5574745 | — | — | 1 | 5.55 |
| CHEMBL5593609 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5594061 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL5568824 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL5571331 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL5574745 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL5593609 | — | IC50 | = | 3420.0 | nM | 5.47 |