Assay Detail
Functional
CHEMBL5553722
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Disruption of epithelial integrity in human Caco-2 cells assessed as change in TEER modulation after 8 days
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational <i>In Silico</i> Design of Selective TMPRSS6 Peptidomimetic Inhibitors via Exploitation of the S2 Subpocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.48 | 7.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081543 | — | — | 1 | 7.74 |
| CHEMBL5562937 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081543 | — | IC50 | = | 18.1 | nM | 7.74 |
| CHEMBL5562937 | — | IC50 | = | 6100.0 | nM | 5.21 |