Assay Detail
Functional
CHEMBL5554459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human K562 cells incubated for 2 hrs followed by compound washout and measured after 72 hrs by Celltiter-blue viability assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel <i>N,N</i>-Dimethyl-idarubicin Analogues Are Effective Cytotoxic Agents for ABCB1-Overexpressing, Doxorubicin-Resistant Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.07 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5434379 | — | — | 1 | 7.72 |
| CHEMBL1117 | IDARUBICIN | 4.0 | 1 | 7.57 |
| CHEMBL3303266 | — | — | 1 | 7.42 |
| CHEMBL457065 | — | — | 1 | 7.11 |
| CHEMBL5407417 | — | — | 1 | 7.01 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 6.85 |
| CHEMBL5407496 | — | — | 1 | 6.85 |
| CHEMBL417 | EPIRUBICIN | 4.0 | 1 | 6.62 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5434379 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1117 | IDARUBICIN | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3303266 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL457065 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5407417 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL5407496 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL417 | EPIRUBICIN | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 325.0 | nM | 6.49 |