Assay Detail
Functional
CHEMBL5554460
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Cytotoxicity against human K562 cells overexpressing ABCB1 incubated for 2 hrs followed by compound washout and measured after 72 hrs by Celltiter-blue viability assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel <i>N,N</i>-Dimethyl-idarubicin Analogues Are Effective Cytotoxic Agents for ABCB1-Overexpressing, Doxorubicin-Resistant Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.62 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5434379 | — | — | 1 | 7.50 |
| CHEMBL1117 | IDARUBICIN | 4.0 | 1 | 7.39 |
| CHEMBL3303266 | — | — | 1 | 7.13 |
| CHEMBL457065 | — | — | 1 | 7.04 |
| CHEMBL5407417 | — | — | 1 | 6.73 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 6.16 |
| CHEMBL5407496 | — | — | 1 | 6.16 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.80 |
| CHEMBL417 | EPIRUBICIN | 4.0 | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5434379 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1117 | IDARUBICIN | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3303266 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL457065 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL5407417 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 686.0 | nM | 6.16 |
| CHEMBL5407496 | — | IC50 | = | 686.0 | nM | 6.16 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1587.0 | nM | 5.80 |
| CHEMBL417 | EPIRUBICIN | IC50 | = | 2038.0 | nM | 5.69 |