Assay Detail
Binding
CHEMBL5554635
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human P2X3 receptor expressed in 1321N1 cells assessed as reduction in calcium level preincubated for 3 mins followed by alpha, beta-meATP addition and measured after 3 mins by Fluo-4 AM dye based microplate reader assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 1321N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 7.66 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL596234 | A-317491 | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL596234 | A-317491 | Ki | = | 22.0 | nM | 7.66 |