Assay Detail
Functional
CHEMBL5554802
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 3 days by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovering New Metallo-Deubiquitinase CSN5 Inhibitors by a Non-Catalytic Activity Assay Platform.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.51 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5574229 | — | — | 1 | 4.85 |
| CHEMBL5566554 | — | — | 1 | 4.65 |
| CHEMBL5572586 | — | — | 1 | 4.64 |
| CHEMBL5572812 | — | — | 1 | 4.47 |
| CHEMBL5569845 | — | — | 1 | 4.28 |
| CHEMBL5575733 | — | — | 1 | 4.17 |
| CHEMBL5573752 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5574229 | — | IC50 | = | 14020.0 | nM | 4.85 |
| CHEMBL5566554 | — | IC50 | = | 22440.0 | nM | 4.65 |
| CHEMBL5572586 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL5572812 | — | IC50 | = | 34150.0 | nM | 4.47 |
| CHEMBL5569845 | — | IC50 | = | 52460.0 | nM | 4.28 |
| CHEMBL5575733 | — | IC50 | = | 68280.0 | nM | 4.17 |
| CHEMBL5573752 | — | IC50 | > | 100000.0 | nM | - |