Assay Detail
Binding
CHEMBL5576163
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Inhibition of ATR (unknown origin)
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the first ataxia telangiectasia and Rad3-related (ATR) degraders for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.19 | 9.82 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4650286 | M4344 | 1.0 | 1 | 9.82 |
| CHEMBL3989870 | BERZOSERTIB | 2.0 | 1 | 9.77 |
| CHEMBL4285417 | CERALASERTIB | 3.0 | 1 | 9.00 |
| CHEMBL4647810 | ELIMUSERTIB | 1.0 | 1 | 8.15 |
| CHEMBL5593857 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4650286 | M4344 | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL3989870 | BERZOSERTIB | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL4285417 | CERALASERTIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4647810 | ELIMUSERTIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5593857 | — | Inhibition | - | % | - |