Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5576225

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human GIPR expressed in CHO cells assessed as increase in cAMP production incubated for 30 mins by Eu-cAMP tracer based microplate reader analysis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Gastric inhibitory polypeptide receptor (CHEMBL4383)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design of a novel long-acting dual GLP-1/GIP receptor agonist.
Dong Y, Zhang J, Xu H, Shen H, Lu Q, Feng J, Cai Z.
Bioorg Med Chem (2024) 100 : 117630 -117630
PubMed 38330849 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 25 9.21 10.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5591096 1 10.92
CHEMBL4297839 TIRZEPATIDE 4.0 1 10.52
CHEMBL5591192 1 10.22
CHEMBL5584064 1 10.19
CHEMBL5584078 1 9.96
CHEMBL5589666 1 9.85
CHEMBL5595217 1 9.85
CHEMBL5589598 1 9.70
CHEMBL5589947 1 9.41
CHEMBL5579723 1 9.38
CHEMBL5593339 1 9.34
CHEMBL5590213 1 9.22
CHEMBL5593080 1 9.17
CHEMBL5579773 1 9.14
CHEMBL5595184 1 8.95
CHEMBL5594125 1 8.88
CHEMBL5589823 1 8.88
CHEMBL5590197 1 8.73
CHEMBL5590399 1 8.63
CHEMBL5583949 1 8.59
CHEMBL5593989 1 8.56
CHEMBL5595154 1 8.43
CHEMBL5591244 1 8.14
CHEMBL5594494 1 7.83
CHEMBL5595654 1 7.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5591096 EC50 = 0.012 nM 10.92
CHEMBL4297839 TIRZEPATIDE EC50 = 0.03 nM 10.52
CHEMBL5591192 EC50 = 0.06 nM 10.22
CHEMBL5584064 EC50 = 0.064 nM 10.19
CHEMBL5584078 EC50 = 0.11 nM 9.96
CHEMBL5589666 EC50 = 0.14 nM 9.85
CHEMBL5595217 EC50 = 0.14 nM 9.85
CHEMBL5589598 EC50 = 0.2 nM 9.70
CHEMBL5589947 EC50 = 0.39 nM 9.41
CHEMBL5579723 EC50 = 0.42 nM 9.38
CHEMBL5593339 EC50 = 0.46 nM 9.34
CHEMBL5590213 EC50 = 0.6 nM 9.22
CHEMBL5593080 EC50 = 0.67 nM 9.17
CHEMBL5579773 EC50 = 0.73 nM 9.14
CHEMBL5595184 EC50 = 1.12 nM 8.95
CHEMBL5594125 EC50 = 1.31 nM 8.88
CHEMBL5589823 EC50 = 1.31 nM 8.88
CHEMBL5590197 EC50 = 1.87 nM 8.73
CHEMBL5590399 EC50 = 2.33 nM 8.63
CHEMBL5583949 EC50 = 2.57 nM 8.59
CHEMBL5593989 EC50 = 2.76 nM 8.56
CHEMBL5595154 EC50 = 3.73 nM 8.43
CHEMBL5591244 EC50 = 7.2 nM 8.14
CHEMBL5594494 EC50 = 14.78 nM 7.83
CHEMBL5595654 EC50 = 19.19 nM 7.72