Assay Detail

CHEMBL5576487

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Functional

Antiviral activity against SARS-CoV-1 infected African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect incubated for 3 days

ChEMBL ↗

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Target

SARS-CoV (CHEMBL4303836) ↗

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Primary target SARS-CoV

CHEMBL4303836

Anchored from Assay target.

Protein identity SARS-CoV

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Severe acute respiratory syndrome-related coronavirus
Cell Type	Vero E6
Confidence	1 — Organism
Curated By	Autocuration

Target

SARS-CoV (CHEMBL4303836) ↗

Type	ORGANISM
Organism	Severe acute respiratory syndrome-related coronavirus

Publication

A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.

Allerton CMN, Arcari JT, Aschenbrenner LM, Avery M, Bechle BM, Behzadi MA, Boras B, Buzon LM, Cardin RD, Catlin NR, Carlo AA, Coffman KJ, Dantonio A, Di L, Eng H, Farley KA, Ferre RA, Gernhardt SS, Gibson SA, Greasley SE, Greenfield SR, Hurst BL, Kalgutkar AS, Kimoto E, Lanyon LF, Lovett GH, Lian Y, Liu W, Martínez Alsina LA, Noell S, Obach RS, Owen DR, Patel NC, Rai DK, Reese MR, Rothan HA, Sakata S, Sammons MF, Sathish JG, Sharma R, Steppan CM, Tuttle JB, Verhoest PR, Wei L, Yang Q, Yurgelonis I, Zhu Y.
J Med Chem (2024) 67 : 13550 -13571
PubMed 38687966 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.80	6.80

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5591580	IBUZATRELVIR	2.0	1	6.80

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5591580	IBUZATRELVIR	EC50	=	157.0	nM	6.80