Assay Detail
Functional
CHEMBL5576558
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
33
Total Activities
33
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxicity of novel 6,8,9-trisubstituted purine analogs against liver cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.63 | 5.62 |
| Activity | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 5.62 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.46 |
| CHEMBL5590468 | — | — | 1 | 5.21 |
| CHEMBL5593504 | — | — | 1 | 5.14 |
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 4.82 |
| CHEMBL5593866 | — | — | 1 | 4.82 |
| CHEMBL5592853 | — | — | 1 | 4.76 |
| CHEMBL5594744 | — | — | 1 | 4.70 |
| CHEMBL5583671 | — | — | 1 | 4.67 |
| CHEMBL5584080 | — | — | 1 | 4.67 |
| CHEMBL5590177 | — | — | 1 | 4.61 |
| CHEMBL5583634 | — | — | 1 | 4.59 |
| CHEMBL5591090 | — | — | 1 | 4.58 |
| CHEMBL5593967 | — | — | 1 | 4.52 |
| CHEMBL5592562 | — | — | 1 | 4.52 |
| CHEMBL5590227 | — | — | 1 | 4.51 |
| CHEMBL5594900 | — | — | 1 | 4.49 |
| CHEMBL5591158 | — | — | 1 | 4.45 |
| CHEMBL5592703 | — | — | 1 | 4.32 |
| CHEMBL5584013 | — | — | 1 | 4.29 |
| CHEMBL5594130 | — | — | 1 | 4.24 |
| CHEMBL5595626 | — | — | 1 | 4.23 |
| CHEMBL5594145 | — | — | 1 | 4.22 |
| CHEMBL5593558 | — | — | 1 | 4.17 |
| CHEMBL5595712 | — | — | 1 | 4.16 |
| CHEMBL5591318 | — | — | 1 | - |
| CHEMBL5589714 | — | — | 1 | - |
| CHEMBL5591382 | — | — | 1 | - |
| CHEMBL5592087 | — | — | 1 | - |
| CHEMBL5591093 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1619 | CLADRIBINE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5590468 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5593504 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1568 | FLUDARABINE | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL5593866 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5592853 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL5594744 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL5583671 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL5584080 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL5590177 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL5583634 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL5591090 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL5593967 | — | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL5592562 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL5590227 | — | IC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL5594900 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL5591158 | — | IC50 | = | 35800.0 | nM | 4.45 |
| CHEMBL5592703 | — | IC50 | = | 47500.0 | nM | 4.32 |
| CHEMBL5584013 | — | IC50 | = | 51600.0 | nM | 4.29 |
| CHEMBL5594130 | — | IC50 | = | 57900.0 | nM | 4.24 |
| CHEMBL5595626 | — | IC50 | = | 58400.0 | nM | 4.23 |
| CHEMBL5594145 | — | IC50 | = | 60700.0 | nM | 4.22 |
| CHEMBL5593558 | — | IC50 | = | 68200.0 | nM | 4.17 |
| CHEMBL5595712 | — | IC50 | = | 69800.0 | nM | 4.16 |
| CHEMBL5591318 | — | Activity | - | — | - | |
| CHEMBL5589714 | — | Activity | - | — | - | |
| CHEMBL5591382 | — | Activity | - | — | - | |
| CHEMBL5592087 | — | Activity | - | — | - | |
| CHEMBL5591093 | — | Activity | - | — | - | |
| CHEMBL5593906 | — | Activity | - | — | - | |
| CHEMBL5590658 | — | Activity | - | — | - | |
| CHEMBL5593557 | — | Activity | - | — | - |