Assay Detail
Binding
CHEMBL5576772
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ACTR2B (unknown origin) by TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel thiazole-derivatives as potent ALK5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.70 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5591770 | — | — | 1 | 7.75 |
| CHEMBL5595138 | — | — | 1 | 7.16 |
| CHEMBL5594704 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5591770 | — | IC50 | = | 17.9 | nM | 7.75 |
| CHEMBL5595138 | — | IC50 | = | 68.9 | nM | 7.16 |
| CHEMBL5594704 | — | IC50 | = | 6344.0 | nM | 5.20 |