Assay Detail
Binding
CHEMBL5576841
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Inhibition of HIV-1 integrase strand transfer activity
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
The role of the methoxy group in approved drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.93 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379664 | — | — | 1 | 7.62 |
| CHEMBL270717 | — | — | 1 | 7.36 |
| CHEMBL382680 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379664 | — | IC50 | = | 24.2 | nM | 7.62 |
| CHEMBL270717 | — | IC50 | = | 43.5 | nM | 7.36 |
| CHEMBL382680 | — | IC50 | = | 1600.0 | nM | 5.80 |