Assay Detail
Binding
CHEMBL5576844
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV-1 integrase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
The role of the methoxy group in approved drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.44 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105735 | ASUNAPREVIR | 4.0 | 1 | 9.00 |
| CHEMBL3125106 | — | — | 1 | 8.70 |
| CHEMBL3128331 | — | — | 1 | 8.15 |
| CHEMBL5594789 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105735 | ASUNAPREVIR | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3125106 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3128331 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5594789 | — | IC50 | = | 12.0 | nM | 7.92 |