Assay Detail
Functional
CHEMBL5577179
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Inhibition of LPS-induced MCP-1 production in mouse Monocyte
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Monocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a potent orally available pyrazolopyridone derivative as a novel selective bromodomain and extra-terminal domain (BET)-first bromodomain (BD1) inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.85 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5584084 | — | — | 1 | 9.00 |
| CHEMBL1957266 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5584084 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1957266 | — | IC50 | = | 2.0 | nM | 8.70 |